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Van Rooj et. al. demonstrated that the inhibition of miR-208a by systemic delivery of locked nucleic acid–modified antisense oligonucleotide prevented cardiac remodeling in a rat model of LV failure. This technology also prevented pathological myosin switching and cardiac remodeling, while improving cardiac function .
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Ejection fraction (EF) measures the amount of blood pumped out of your heart 's lower chambers, or ventricles. It's the percentage of blood that leaves your ventricle when your heart.
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